内毒素预处理家兔中磺胺二甲嘧啶的药代动力学和代谢变化
Changes of pharmacokinetics and metabolism of sulfadimidine in endotoxin pretreated rabbits.
作者信息
Lapka R, Langmeierová M, Vanêĉek J, Raŝková H
出版信息
Arch Toxicol Suppl. 1980;4:325-7. doi: 10.1007/978-3-642-67729-8_67.
PMID:6933928
Abstract
Changes of pharmacokinetics and acetylation of sulfadimidine (SDM) were studied in endotoxin pretreated rabbits. With increasing doses of endotoxin the levels of intravenously administered SDM were lower. The acetylation rate was reduced in urine of rabbits after medium endotoxin doses.
摘要
在内毒素预处理的家兔中研究了磺胺二甲嘧啶（SDM）的药代动力学和乙酰化变化。随着内毒素剂量增加，静脉注射的SDM水平降低。中等剂量内毒素处理后，家兔尿液中的乙酰化率降低。
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