内毒素预处理家兔中磺胺二甲嘧啶的药代动力学和代谢变化
Changes of pharmacokinetics and metabolism of sulfadimidine in endotoxin pretreated rabbits.
作者信息
Lapka R, Langmeierová M, Vanêĉek J, Raŝková H
出版信息
Arch Toxicol Suppl. 1980;4:325-7. doi: 10.1007/978-3-642-67729-8_67.
PMID:6933928
Abstract
Changes of pharmacokinetics and acetylation of sulfadimidine (SDM) were studied in endotoxin pretreated rabbits. With increasing doses of endotoxin the levels of intravenously administered SDM were lower. The acetylation rate was reduced in urine of rabbits after medium endotoxin doses.
摘要
在内毒素预处理的家兔中研究了磺胺二甲嘧啶（SDM）的药代动力学和乙酰化变化。随着内毒素剂量增加，静脉注射的SDM水平降低。中等剂量内毒素处理后，家兔尿液中的乙酰化率降低。
相似文献
1
Changes of pharmacokinetics and metabolism of sulfadimidine in endotoxin pretreated rabbits.内毒素预处理家兔中磺胺二甲嘧啶的药代动力学和代谢变化
Arch Toxicol Suppl. 1980;4:325-7. doi: 10.1007/978-3-642-67729-8_67.
2
The acetylation-deacetylation equilibrium of sulfadimidine in ruminant calves.
Vet Q. 1983;5(1):41-8. doi: 10.1080/01652176.1983.9693871.
3
Estrogen-dependent differences in the acetylation of sulfadimidine in the rat.
Pharmacology. 1979;19(4):209-14. doi: 10.1159/000137312.
4
Endotoxin and pharmacokinetics of rifampicin.利福平的内毒素与药代动力学
Arch Toxicol Suppl. 1985;8:211-5. doi: 10.1007/978-3-642-69928-3_32.
5
Pharmacokinetics, metabolism, and renal excretion of sulfadimidine and its N4-acetyl and hydroxy metabolites in humans.
Ther Drug Monit. 1986;8(4):434-9. doi: 10.1097/00007691-198612000-00010.
6
7
Pharmacokinetics of sulfadimidine and its N4-acetyl metabolite in healthy and diseased rabbits infected with Pasteurella multocida.磺胺二甲嘧啶及其N4-乙酰代谢物在感染多杀性巴氏杆菌的健康和患病兔体内的药代动力学
J Vet Pharmacol Ther. 1990 Jun;13(2):192-7. doi: 10.1111/j.1365-2885.1990.tb00768.x.
8
[Pharmacokinetic studies of sulfamerazine-Na, sulfaperine-Na and sulfadimidine-Na in the hen].
Arch Exp Veterinarmed. 1980;34(4):587-94.
9
Acetylation and hydroxylation of sulfadimidine by the turtle Cuora amboniensis.锯缘摄龟对磺胺二甲嘧啶的乙酰化和羟基化作用
J Vet Pharmacol Ther. 1986 Sep;9(3):330-2. doi: 10.1111/j.1365-2885.1986.tb00049.x.
10
Disposition of sulfadimidine and its N4-acetyl and hydroxy metabolites in horse plasma.
J Vet Pharmacol Ther. 1985 Sep;8(3):303-11. doi: 10.1111/j.1365-2885.1985.tb00960.x.
引用本文的文献
1
Changes of pharmacokinetics of trimethoprim after pretreatment with streptococcal peptidoglycan.用链球菌肽聚糖预处理后甲氧苄啶的药代动力学变化。
Eur J Drug Metab Pharmacokinet. 1986 Jan-Mar;11(1):17-22. doi: 10.1007/BF03189770.
2
Effect of the immunomodulator tilorone on the in vivo acetylation of procainamide in the rat.免疫调节剂泰洛龙对大鼠体内普鲁卡因酰胺乙酰化的影响。
Pharm Res. 1989 Jun;6(6):477-80. doi: 10.1023/a:1015964306318.
Zotero 插件