利福平的内毒素与药代动力学

Endotoxin and pharmacokinetics of rifampicin.

作者信息

Lavický J, Celeda L, Urbanová Z, Kvĕtina J, Vanĕcek J, Rasková H

出版信息

Arch Toxicol Suppl. 1985;8:211-5. doi: 10.1007/978-3-642-69928-3_32.

Abstract

Changes of pharmacokinetics of rifampicin (20 mg . kg-1 orally) were seen in rabbits pretreated with 0.02, 0.2 and 2.0 micrograms . kg-1 of endotoxin S. typhimurium given intravenously. The animals served as their own controls. The two higher endotoxin doses induced significantly lower plasma levels and changes in the absorption and elimination phase. After the lowest endotoxin dose the results were variable. Tolerance to pyrogenicity of endotoxin, produced by daily toxin administration abolished the otherwise induced changes in rifampicin pharmacokinetics.

摘要

给兔静脉注射0.02、0.2和2.0微克·千克⁻¹鼠伤寒沙门氏菌内毒素进行预处理后，观察到口服20毫克·千克⁻¹利福平的药代动力学变化。动物自身作为对照。两种较高剂量的内毒素导致血浆水平显著降低，并使吸收和消除阶段发生变化。最低内毒素剂量组的结果则不一致。每日给予毒素产生的对内毒素热原性的耐受性消除了利福平药代动力学中原本会出现的变化。