Halatcheva L, Nikolova P
Arch Toxicol Suppl. 1980;4:355-7. doi: 10.1007/978-3-642-67729-8_76.
The authors report their experimental data from a several years long study of the influence of Lead (Pb), Manganese (Mn), and Mercury (Hg) upon the free amino acid concentrations in the liver of rats. Comparing the effects of the metals investigated they established that the disorders caused by Pb and Mn become more serious with time after poisoning, while Hg shows early influence and changes. The concentration of the sulfur-containing amino acids (methionine and cysteine) decreases considerably under the influence of Pb and Mn. Mercury tends to produce an increase of the cysteine content, whilst methionine, after an initial elevation, gradually decreases to values similar to those of the controls.
作者报告了他们在一项长达数年的研究中获得的实验数据，该研究旨在探究铅（Pb）、锰（Mn）和汞（Hg）对大鼠肝脏中游离氨基酸浓度的影响。通过比较所研究金属的影响，他们发现铅和锰中毒后导致的紊乱会随着时间推移而变得更加严重，而汞则表现出早期影响和变化。在铅和锰的影响下，含硫氨基酸（蛋氨酸和半胱氨酸）的浓度显著降低。汞往往会使半胱氨酸含量增加，而蛋氨酸在最初升高后，会逐渐降至与对照组相似的值。
