镉、铅和汞预处理大鼠中的庆大霉素肾毒性

Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats.

作者信息

Viau C, Bernard A, Lauwerys R R, Tulkens P, Laurent G, Maldague P

出版信息

Toxicology. 1983 May;27(1):15-25. doi: 10.1016/0300-483x(83)90072-0.

Abstract

The effect of a previous chronic exposure to cadmium, lead or inorganic mercury on the nephrotoxic potential of gentamicin was investigated in female Sprague-Dawley rats. A daily dose of 10 mg gentamicin/kg body weight/day was administered for 21 days to rats having a renal load of 168 micrograms Cd, 35 micrograms Pb or 129 micrograms Hg/g whole kidney. Urine analysis suggests an attenuation of the nephrotoxic potential of gentamicin while a microscopical examination of kidneys indicates a superimposition of the effects of the metals and the antibiotics. The only clear interaction observed consists in a reduction of gentamicin accumulation in the cortex of cadmium-treated animals. It is concluded that none of the metal pretreatments potentiates the nephrotoxic effects of gentamicin.

摘要

在雌性斯普拉格-道利大鼠中，研究了先前长期接触镉、铅或无机汞对庆大霉素肾毒性潜力的影响。对全肾肾负荷为168微克镉、35微克铅或129微克汞的大鼠，每日给予10毫克庆大霉素/千克体重，持续21天。尿液分析表明庆大霉素的肾毒性潜力有所减弱，而肾脏的显微镜检查表明金属和抗生素的作用相互叠加。观察到的唯一明显相互作用是镉处理动物皮质中庆大霉素积累减少。得出的结论是，金属预处理均未增强庆大霉素的肾毒性作用。