萘啶酸通过母乳的排泄情况。

Excretion of nalidixic acid via mother's milk.

作者信息

Traeger A, Peiker G

出版信息

Arch Toxicol Suppl. 1980;4:388-90. doi: 10.1007/978-3-642-67729-8_85.

Abstract

Following the oral administration of 2.0 g nalidixic acid (NA) to lactating women only 0.003% of the dose was excreted chemotherapeutically active in the total 24 h milk. In milk, minimal inhibitory concentrations of nalidixic acid were never reached. 6-8 h after medication the milk/serum quotient was 0.061 +/- 0.003.

摘要

哺乳期妇女口服2.0克萘啶酸（NA）后，在24小时的总乳汁中，仅0.003%的剂量以具有化疗活性的形式排泄。在乳汁中，从未达到萘啶酸的最低抑菌浓度。用药后6 - 8小时，乳汁/血清商数为0.061±0.003。