Mathew R J, Ho B T, Kralik P, Taylor D, Semchuk K, Weinman M, Claghorn J L
Psychiatry Res. 1980 Sep;3(1):85-91. doi: 10.1016/0165-1781(80)90050-5.
Levels of anxiety, plasma epinephrine and norpinephrine, and red blood cell (RBC) catechol-O-methyltransferase (COMT) activity were measured before and after 4 weeks of relaxation training in a group of 15 drug-free, anxious subjects and at a similar interval in a group of 15 drug-free, healthy controls. The index group showed significant decreases in levels of anxiety and plasma epinephrine and norepinephrine after treatment. No changes were observed in the control values. RBC COMT did not show any significant differences in activity between the index and control groups and between the pre- and posttreatment values. Similarly, COMT activity levels failed to correlate with levels of anxiety and catecholamines before or after treatment. These findings indicate that anxiety is unlikely to have an effect on RBC COMT activity, whereas it has a direct effect on plasma catecholamines.
对15名未服用药物的焦虑受试者进行了4周放松训练，在训练前后测量了他们的焦虑水平、血浆肾上腺素和去甲肾上腺素水平以及红细胞（RBC）儿茶酚-O-甲基转移酶（COMT）活性；同时对15名未服用药物的健康对照者在类似的时间间隔内进行了测量。指标组在治疗后焦虑水平、血浆肾上腺素和去甲肾上腺素水平显著降低。对照组的值未观察到变化。RBC COMT在指标组和对照组之间以及治疗前和治疗后的值之间的活性没有显示出任何显著差异。同样，COMT活性水平在治疗前后与焦虑水平和儿茶酚胺水平均无相关性。这些发现表明，焦虑不太可能对RBC COMT活性产生影响，而对血浆儿茶酚胺有直接影响。
