伯氨喹在人体中的血浆动力学及尿排泄情况。
Plasma kinetics and urinary excretion of primaquine in man.
作者信息
Greaves J, Evans D A, Gilles H M, Fletcher K A, Bunnag D, Harinasuta T
出版信息
Br J Clin Pharmacol. 1980 Oct;10(4):399-404. doi: 10.1111/j.1365-2125.1980.tb01777.x.
Abstract
1 The kinetics of primaquine have been studied in twenty volunteers after single and multiple dose regimes. 2 The kinetic parameters were similar in glucose-6-phosphate dehydrogenase (G6PD) normal Thais, G6PD deficient Thais and in Caucasians. 3 The Caucasian subjects showed about 1% of the dose was excreted in the urine. 4 The kinetic parameters obtained from multiple dose studies in Thais were very similar to those obtained from single dose studies in Thais.
摘要
已在20名志愿者身上研究了伯氨喹在单次和多次给药方案后的动力学情况。
葡萄糖-6-磷酸脱氢酶（G6PD）正常的泰国人、G6PD缺乏的泰国人和高加索人的动力学参数相似。
高加索受试者尿液中排出的药物剂量约为给药量的1%。
从泰国人的多次给药研究中获得的动力学参数与从泰国人的单次给药研究中获得的参数非常相似。
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