服用伯氨喹：氯喹方案后人体尿液中伯氨喹的排泄及红细胞高铁血红蛋白水平
Urinary primaquine excretion and red cell methaemoglobin levels in man following a primaquine:chloroquine regimen.
作者信息
Greaves J, Evans D A, Fletcher K A
出版信息
Br J Clin Pharmacol. 1980 Sep;10(3):293-5. doi: 10.1111/j.1365-2125.1980.tb01758.x.
Abstract
1 Red cell methaemoglobin levels were found to be significantly raised in healthy subjects given a 14-day course of primaquine with chloroquine on the first 3 days. 2 The methaemoglobin levels were not related to the quantity of primaquine excreted. 3 No primaquine could be detected in the plasma at 24 h following the last three daily doses.
摘要
- 发现给予14天疗程伯氨喹且在前3天加用氯喹的健康受试者，其红细胞高铁血红蛋白水平显著升高。2. 高铁血红蛋白水平与排出的伯氨喹量无关。3. 在最后3次每日给药后24小时，血浆中未检测到伯氨喹。
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本文引用的文献
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Toxicity of primaquine in Caucasians.伯氨喹对高加索人的毒性。
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PRIMAQUINE AND METHEMOGLOBIN.伯氨喹与高铁血红蛋白
Clin Pharmacol Ther. 1964 May-Jun;5:307-9. doi: 10.1002/cpt196453307.
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Korean vivax malaria. III. Curative effect and toxicity of primaquine in doses from 10 to 30 mg. daily.韩国间日疟。III. 每日10至30毫克伯氨喹的疗效和毒性。
Am J Trop Med Hyg. 1953 Nov;2(6):977-82.
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A selected ion monitoring assay for primaquine in plasma and urine.
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