Hofmeister B G, Carrera C J, Barrett S G
Blood. 1981 Feb;57(2):372-6.
The presence of complement and Fc receptors on neutrophils from patients with acute leukemia was investigated at different stages of the leukemic process. Both Fc receptors (Fc-H and Fc-R) and one complement receptor (C3d) were normal when patients were studied at diagnosis, in relapse, and in remission. In contrast, the C3b receptor was significantly reduced on te neutrophils at the time of diagnosis, but returned to normal levels when patients entered remission. Variable amounts of C3b activity were observed in patients relapse, with approximately one-half of the patients showing decreased C3b activity. To determine whether the reduction inC3b receptors was specific for patients at diagnosis, three patients were studied at different times during their diseases. Normal receptor levels were detected in these patients during remission, but the C3b receptor was markedly reduced at diagnosis and at relapse.
在白血病病程的不同阶段，对急性白血病患者中性粒细胞上补体受体和Fc受体的存在情况进行了研究。在诊断、复发和缓解期对患者进行研究时，Fc受体（Fc-H和Fc-R）和一种补体受体（C3d）均正常。相比之下，诊断时中性粒细胞上的C3b受体显著减少，但患者进入缓解期时恢复到正常水平。在复发患者中观察到不同量的C3b活性，约一半患者的C3b活性降低。为了确定C3b受体减少是否是诊断时患者特有的情况，对三名患者在疾病的不同时间进行了研究。这些患者在缓解期检测到正常的受体水平，但在诊断和复发时C3b受体明显减少。
