Ferri G L, Sternini C, Bonora G, Vezzadini P, Labò G
Scand J Gastroenterol Suppl. 1980;62:49-52.
Serum trypsin-like immunoreactivity (TLI) was studied after administration of secretin (GIH, 75 CU i.v.) in 10 alcoholics and in 3 patients with type IV hyperlipoproteinemia. A significant increase of TLI was observed after secretin administration and persisted throughout the test. In order to assess the possibility of an acid-sensitive effect, the test was repeated on a different day, one hour after the administration of cimetidine (400 mg. p.o.). Cimetidine did not affect serum TLI for one hour, but did reduce significantly the response of serum TLI to injection of secretin (p < 0.01). Some studies were performed, which failed to show any effect of cimetidine on pancreatic exocrine function. However, they were based on the measurement of pancreatic secretion into the duodenum, which required aspiration of gastric secretion from the stomach before entering the duodenum. Therefore, the reduction of TLI response to injection of secretin may be tentatively attributed to the inhibition of gastric acid secretion and delivery to the duodenum caused by cimetidine. If an endogenous acid-sensitive mechanism is involved, it is unlikely to be mediated by secretin.
对10名酗酒者和3名IV型高脂蛋白血症患者静脉注射促胰液素（胃肠抑制素，75 CU）后，研究了血清类胰蛋白酶免疫反应性（TLI）。注射促胰液素后观察到TLI显著增加，且在整个测试过程中持续存在。为了评估酸敏感效应的可能性，在不同日期，于口服西咪替丁（400 mg）1小时后重复该测试。西咪替丁在1小时内未影响血清TLI，但显著降低了血清TLI对注射促胰液素的反应（p < 0.01）。进行了一些研究，但未显示西咪替丁对胰腺外分泌功能有任何影响。然而，这些研究基于对十二指肠内胰腺分泌的测量，这需要在进入十二指肠之前从胃中抽吸胃液。因此，注射促胰液素后TLI反应的降低可能初步归因于西咪替丁对胃酸分泌和向十二指肠输送的抑制。如果涉及内源性酸敏感机制，则不太可能由促胰液素介导。
