Vezzadini P, Ferri G L, Bonora G, Sternini C, Tomassetti P, Salvi M, Labò G
Clin Chim Acta. 1981 Apr 9;111(2-3):163-7. doi: 10.1016/0009-8981(81)90183-2.
Serum trypsin-like immunoreactivity (TLI) was studied in alcoholics without evidence of pancreatic disease and in controls. Basal values were 29 +/- 4.6 microgram/l (mean +/- S.E.M) in alcoholics and 23 +/- 4.4 microgram/l in controls (p not significant). The injection of secretin was followed by a significant increase of serum TLI in both groups; the integrated trypsin output (ITO) in the first hour after secretin administration was 947 +/- 403 (mean +/- S.E.M.) in alcoholics and 76 +/- 15 in controls (p less than 0.05). In 9 (75%) of the alcoholics tested, ITO was higher than the highest ITO of controls. The increase of serum TLI after injection of secretin is probably due to secretion and/or regurgitation of trypsinogen into the bloodstream when the pancreas is stimulated with intravenous secretin. In the light of experimental studies on chronic ethanol intoxication in animals, the increased ITO observed in alcoholics may suggest obstruction to pancreatic secretory flow in spite of the absence of any clinical sign of pancreatic disease.
在无胰腺疾病证据的酗酒者和对照组中研究了血清类胰蛋白酶免疫反应性（TLI）。酗酒者的基础值为29±4.6微克/升（平均值±标准误），对照组为23±4.4微克/升（p无显著性差异）。两组在注射促胰液素后血清TLI均显著升高；酗酒者在注射促胰液素后第一小时的胰蛋白酶综合输出量（ITO）为947±403（平均值±标准误），对照组为76±15（p<0.05）。在9名（75%）接受测试的酗酒者中，ITO高于对照组的最高ITO。注射促胰液素后血清TLI升高可能是由于静脉注射促胰液素刺激胰腺时胰蛋白酶原分泌和/或反流进入血液。根据对动物慢性乙醇中毒的实验研究，尽管没有任何胰腺疾病的临床体征，但在酗酒者中观察到的ITO增加可能提示胰腺分泌流受阻。
