Myllylä V V, Ala-Hurula V, Arvela P, Kärki N, Hokkanen E
Ups J Med Sci Suppl. 1980;31:20-2.
There seems to be great individual differences in the bioavailability of ergotamine in continuous use. The great tolerance to ergotamine in some patients using the drug on a daily basis, even in high doses, may be due to the low-bioavailability of ergotamine in these subjects. This may also explain the infrequency of serious complications among migraine patients.
连续使用时，麦角胺的生物利用度似乎存在很大的个体差异。一些每日使用该药的患者，即使大剂量使用，对麦角胺仍有很大耐受性，这可能是由于这些患者体内麦角胺的生物利用度较低。这也可能解释了偏头痛患者中严重并发症发生率较低的原因。
