Ala-Hurula V, Myllylä V V, Arvela P, Kärki N T, Hokkanen E
Ups J Med Sci Suppl. 1980;31:7-9.
The studies presented indicate that ergotamine tartrate taken orally in single or repeated 2 mg doses is biologically available in most of the subjects examined. The peak plasma concentration of the drug in the ng/ml range is attained at 1-2 hours. It seems probable that there is a second rise in the plasma concentrations of the drug, possibly indicating an accumulation of ergotamine or some of its immunoreactive metabolites, and this needs further evaluation.
所呈现的研究表明，大多数接受检查的受试者口服单次或重复2毫克剂量的酒石酸麦角胺后具有生物利用度。该药物在1至2小时达到纳克/毫升范围内的血浆峰值浓度。药物血浆浓度可能会出现第二次升高，这可能表明麦角胺或其一些免疫反应性代谢物的蓄积，这需要进一步评估。
