Fowler S
Acta Med Scand Suppl. 1980;642:151-8. doi: 10.1111/j.0954-6820.1980.tb10947.x.
A series of biochemical and morphological studies has focused on the properties and origins of lipid laden foam cells in experimentally induced atherosclerosis in rabbits. Lipids inclusions present in these cells occupy half or more of the cytoplasmic volume and are of two kinds: cytoplasmic lipid droplets composed predominantly of cholesteryl esters and lysosomes in which substantial quantities of free cholesterol have accumulated. The foam cells exhibit some properties of macrophages but not others. They possess high levels of acid hydrolases and catalase and Fc membrane receptors can be detected on their surface. Only about one third of the foam cells, however, exhibit C3 receptors and few if any of the cells appear to contain or secrete lysozyme.
一系列生物化学和形态学研究聚焦于兔实验性动脉粥样硬化中脂质负载泡沫细胞的特性和起源。这些细胞中存在的脂质包涵体占据细胞质体积的一半或更多，有两种类型：主要由胆固醇酯组成的细胞质脂滴和积累了大量游离胆固醇的溶酶体。泡沫细胞表现出巨噬细胞的一些特性，但并非全部。它们具有高水平的酸性水解酶和过氧化氢酶，并且在其表面可检测到Fc膜受体。然而，只有约三分之一的泡沫细胞表现出C3受体，几乎没有细胞似乎含有或分泌溶菌酶。
