Zhang Fengwei, Wang Ruirui, Liu Baocheng, Zhang Lei
Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2022 Sep 15;13:977870. doi: 10.3389/fphar.2022.977870. eCollection 2022.
Regulation of autophagy affects the progression of atherosclerosis. In recent years, research on autophagy in atherosclerosis has been widely concerned. However, there is no bibliometric analysis in this field. The purpose of this study was to explore the general situation, hot spots, and trends of the research in this field through bibliometric analysis. Articles related to autophagy in atherosclerosis from 2012 to 2021 were retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace were used for data analysis and visualization of countries, institutions, authors, keywords, journals, and citations. A total of 988 articles were obtained in the last 10 years. The number of publications and citations increased rapidly from 2012 to 2021, especially after 2019. The most productive countries, institutions, journals, and authors were the People's Republic of China, Shandong University, , and Wim Martinet, respectively. The primary keywords were "oxidative stress," "apoptosis," "activated protein kinase," and "inflammation." The burst detection analysis of keywords found that "SIRT1" and "long non-coding RNA" might be regarded as the focus of future research. This is the first bibliometric analysis of autophagy in atherosclerosis, which reports the hot spots and emerging trends. The interaction between oxidative stress and autophagy, programmed cell death, and activated protein kinases are considered to be the current research priorities. Molecular mechanisms and therapeutic target for the intervention of atherosclerosis by regulating autophagy will become an emerging research direction.
自噬调节影响动脉粥样硬化的进展。近年来，动脉粥样硬化中自噬的研究受到广泛关注。然而，该领域尚无文献计量学分析。本研究的目的是通过文献计量学分析来探索该领域研究的总体情况、热点和趋势。从科学网核心合集检索了2012年至2021年与动脉粥样硬化中自噬相关的文章。使用VOSviewer和CiteSpace对国家、机构、作者、关键词、期刊和引文进行数据分析和可视化。在过去10年中总共获得了988篇文章。从2012年到2021年，出版物数量和引文数量迅速增加，尤其是在2019年之后。发文量最多的国家、机构、期刊和作者分别是中国、山东大学、《》（原文此处期刊名缺失）和维姆·马丁内。主要关键词为“氧化应激”“细胞凋亡”“活化蛋白激酶”和“炎症”。关键词的突发检测分析发现，“SIRT1”和“长链非编码RNA”可能被视为未来研究的重点。这是首次对动脉粥样硬化中自噬进行的文献计量学分析，报告了热点和新出现的趋势。氧化应激与自噬、程序性细胞死亡和活化蛋白激酶之间的相互作用被认为是当前的研究重点。通过调节自噬干预动脉粥样硬化的分子机制和治疗靶点将成为一个新的研究方向。
