Castro A, Castillo J, Lema M, Dapena M D, Migallón M L, Cebrián E, Noya M
Med Clin (Barc). 1980 Dec 15;75(10):421-4.
A cytological study of the cerebrospinal fluid from 25 patients with acute leukemias and five patients with malignant lymphomas (Hodgkin's disease and non-Hodgkin's lymphoma) has been performed. All patients had clinical manifestations of central nervous system involvement at the time of lumbar puncture. Cytological abnormalities were observed in 13 out of the 30 samples examined (positivity: 44 percent). The group of 17 patients with lymphoblastic leukemia accounted for the highest cytological positivity (12 our of 17 cases --70.5 percent--). Cerebrospinal fluid from eight patients with acute myeloblastic leukemia and from four patients with Hodgkin's disease was normal. Numerous cell atypias were found in a case of lymphocytic lymphoma. The importance of systematic cytological study of the cerebrospinal fluid in patients with leukemia in order to prevent recurrences and to control intrathecal administration of cytostatics and/or radiotherapy is stressed.
对25例急性白血病患者和5例恶性淋巴瘤患者（霍奇金病和非霍奇金淋巴瘤）的脑脊液进行了细胞学研究。所有患者在腰椎穿刺时均有中枢神经系统受累的临床表现。在所检查的30个样本中，有13个观察到细胞学异常（阳性率：44%）。17例淋巴细胞白血病患者组的细胞学阳性率最高（17例中有12例——70.5%）。8例急性髓细胞白血病患者和4例霍奇金病患者的脑脊液正常。在1例淋巴细胞淋巴瘤患者中发现了许多细胞异型性。强调了对白血病患者脑脊液进行系统细胞学研究对于预防复发以及控制鞘内给予细胞抑制剂和/或放疗的重要性。
