Wright P A, Reed P I, Davies W A, St John D J, Young G P, House F R, Gribble R J, Baron J H
Scand J Gastroenterol Suppl. 1980;65:41-8.
The relationship of serum carbenoxolone to dosage, age, sex, efficacy and side-effects were studied in 92 patients. Log serum carbenoxolone was correlated with dose and with age, and was higher in women. Serum levels were not significantly different in those patients with duodenal (or gastric) ulcer whose ulcers had or had not healed after allowance was made by analysis of variance for the effects of age and sex. However, oedema and hypokalaemia were associated with higher serum levels. These results support the concept that the ulcer-healing effect of carbenoxolone is topical rather than systemic.
在92例患者中研究了血清甘草次酸与剂量、年龄、性别、疗效及副作用之间的关系。血清甘草次酸对数与剂量和年龄相关，且女性患者的血清甘草次酸对数更高。在通过方差分析校正年龄和性别影响后，十二指肠（或胃）溃疡已愈合和未愈合的患者血清水平无显著差异。然而，水肿和低钾血症与较高的血清水平相关。这些结果支持了甘草次酸的溃疡愈合作用是局部而非全身作用的观点。
