Favus M J, Coe F L
Scand J Urol Nephrol Suppl. 1980;53:171-7.
Studies of patients with hyperuricosuria have provided four kinds of evidence linking their hyperuricosuria to calcium stone formation and identifying them as a distinct entity apart from other calcium stone formers. The evidence includes a more virulent natural history of stone disease, in vitro evidence for heterogeneous nucleation of calcium oxalate crystallization by seed crystals for uric acid or sodium hydrogen urate, and a reduction by uric acid or urate of the inhibitory activity which urine normally has upon calcium oxalate crystal growth. The fourth bit of evidence, the dramatic reduction in stone formation rates with allopurinol treatment, will be discussed in detail in a following paper.
对高尿酸尿症患者的研究提供了四类证据，将他们的高尿酸尿症与钙结石形成联系起来，并将他们确定为有别于其他钙结石形成者的独特群体。这些证据包括结石病更严重的自然病程、尿酸或尿酸氢钠籽晶导致草酸钙结晶异质成核的体外证据，以及尿酸或尿酸盐降低尿液通常对草酸钙晶体生长的抑制活性。第四条证据，即使用别嘌呤醇治疗后结石形成率显著降低，将在后续论文中详细讨论。
