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从人垂体中分离γ-促脂素及其氨基酸序列

Isolation and amino acid sequence of gamma-lipotropin from human pituitary glands.

作者信息

Li C H, Chung D, Yamashiro D

出版信息

Proc Natl Acad Sci U S A. 1980 Dec;77(12):7214-7. doi: 10.1073/pnas.77.12.7214.

DOI:10.1073/pnas.77.12.7214
PMID:6938967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350472/
Abstract

gamma-Lipotropin has been purified to homogeneity from human pituitary glands. It consists of 56 amino acids with one residue each of Trp, Thr, Val, Tyr, and Phe. The amino acid sequence has been determined as follows: H-Glu-Leu-Thr-Gly-Gln-Arg-Leu-Arg-Gln-Gly-Asp-Gly-Pro-Asn-Ala-Gly-Ala-Asp-Asp-G ly-Pro-Gly-Ala-Gln-Ala-Asp-Leu-Glu-His-Ser-Leu-Leu-Val-Ala-Ala-Glu-Lys-Lys-Asp- Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp-OH. Comparison with the structure of the ovine and porcine hormones reveals that the 23-amino-acid sequence at the COOH terminus is highly conserved in evolution.

摘要

γ-促脂素已从人垂体中纯化至同质。它由56个氨基酸组成，其中色氨酸、苏氨酸、缬氨酸、酪氨酸和苯丙氨酸各有一个残基。氨基酸序列已确定如下：H-谷氨酸-亮氨酸-苏氨酸-甘氨酸-谷氨酰胺-精氨酸-亮氨酸-精氨酸-谷氨酰胺-甘氨酸-天冬氨酸-甘氨酸-脯氨酸-天冬酰胺-丙氨酸-甘氨酸-丙氨酸-天冬氨酸-天冬氨酸-甘氨酸-脯氨酸-甘氨酸-丙氨酸-谷氨酰胺-丙氨酸-天冬氨酸-亮氨酸-谷氨酸-组氨酸-丝氨酸-亮氨酸-亮氨酸-缬氨酸-丙氨酸-丙氨酸-谷氨酸-赖氨酸-赖氨酸-天冬氨酸-谷氨酸-甘氨酸-脯氨酸-酪氨酸-精氨酸-甲硫氨酸-谷氨酸-组氨酸-苯丙氨酸-精氨酸-色氨酸-甘氨酸-丝氨酸-脯氨酸-脯氨酸-赖氨酸-天冬氨酸-OH。与绵羊和猪激素的结构比较表明，COOH末端的23个氨基酸序列在进化过程中高度保守。

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Proc Natl Acad Sci U S A. 1982 Aug;79(16):5071-5. doi: 10.1073/pnas.79.16.5071.
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本文引用的文献

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Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide.编码促肾上腺皮质激素原肽的人类基因组DNA的结构组织
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4890-4. doi: 10.1073/pnas.77.8.4890.
2
Beta-lipotropin: a new aldosterone-stimulating factor.β-促脂素：一种新的醛固酮刺激因子。
Science. 1980 Jul 11;209(4453):307-8. doi: 10.1126/science.6247763.
3
Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands.从绵羊脑垂体中分离、纯化和鉴定γ-促脂素
Can J Biochem. 1967 Jul;45(7):1163-74. doi: 10.1139/o67-133.
4
Studies on pituitary lactogenic hormone. XXX. The primary structure of the sheep hormone.垂体催乳激素研究。XXX. 绵羊激素的一级结构。
Arch Biochem Biophys. 1970 Dec;141(2):705-37. doi: 10.1016/0003-9861(70)90191-8.
5
Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method.促肾上腺皮质激素。44. 用固相法全合成人体激素。
J Am Chem Soc. 1973 Feb 21;95(4):1310-5. doi: 10.1021/ja00785a049.
6
Stimulation of lipolysis and cyclic AMP accumulation in rabbit fat cells by human growth hormone.人生长激素对兔脂肪细胞脂解作用及环磷酸腺苷积累的刺激
Biochem Biophys Res Commun. 1972 Jul 25;48(2):274-9. doi: 10.1016/s0006-291x(72)80046-9.
7
Isolation of gamma-lipotropic hormone from porcine pituitary glands.从猪垂体中分离γ-促脂素。
Biochim Biophys Acta. 1969 Mar;175(2):444-7. doi: 10.1016/0005-2795(69)90027-0.
8
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Nature. 1965 Dec 11;208(5015):1093-4. doi: 10.1038/2081093b0.
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Biochemistry. 1975 Mar 11;14(5):947-52. doi: 10.1021/bi00676a011.

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