Langlands A O
Aust N Z J Surg. 1981 Feb;51(1):10-2. doi: 10.1111/j.1445-2197.1981.tb05892.x.
The results of cancer management are frequently presented in a way such that the only comparison that can be made between treatments is that of fixed term survival. Very few reports attempt to include an analysis of the effect of second line therapy or a comparison of the different morbidities of different treatments. Techniques now exist (one of these is the concept of treatment utility) which take into account not only the probability of the outcome of a treatment but also the quality of that outcome. To expand this concept requires research in cancer management to be directed to the production of numerical values for treatment toxicity, pain, disability and mutilation, in addition to the conventional survival rates. This paper examines the concept of treatment utility when a comparison is made between two treatments which produce differences in survival but only one of which is associated with significant permanent disability.
癌症治疗结果的呈现方式往往使得不同治疗方法之间唯一能进行的比较就是固定期限生存率的比较。很少有报告尝试纳入二线治疗效果的分析或不同治疗方法不同发病率的比较。现在存在一些技术(其中之一是治疗效用的概念),这些技术不仅考虑治疗结果的概率,还考虑该结果的质量。要扩展这一概念,癌症治疗研究就需要除了传统的生存率之外,还要针对治疗毒性、疼痛、残疾和毁形产生数值。本文探讨了在比较两种治疗方法时治疗效用的概念,这两种治疗方法在生存率上存在差异,但其中只有一种与显著的永久性残疾相关。