青霉胺治疗类风湿关节炎。
Penicillamine in the treatment of rheumatoid arthritis.
作者信息
Camp A V
出版信息
J Rheumatol Suppl. 1981 Jan-Feb;7:103-6.
Between 1973 and 1979, 203 patients with classical or definite rheumatoid arthritis were treated with chloroquine phosphate, gold, or penicillamine. Of 132 receiving penicillamine, 76 received it as the sole treatment. Forty of 50 withdrawals from penicillamine were side effect-related, although 4 of these 50 subsequently resumed therapy. Nineteen showed no response to penicillamine. Eight-six remained on the drug in early 1980. Penicillamine compares favourably with gold with regard to clinical response, number of side effects, and withdrawal rate of the patients on penicillamine.
1973年至1979年间，203例典型或确诊的类风湿性关节炎患者接受了磷酸氯喹、金制剂或青霉胺治疗。在132例接受青霉胺治疗的患者中，76例将其作为唯一治疗药物。50例停用青霉胺的患者中有40例是因副作用，不过这50例中有4例随后又恢复了治疗。19例对青霉胺无反应。1980年初有86例仍在使用该药。在临床反应、副作用数量以及青霉胺治疗患者的停药率方面，青霉胺与金制剂相比更具优势。
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