达那唑对人黄体中甾体激素生成的抑制作用。
Danazol inhibition of steroidogenesis in the human corpus luteum.
作者信息
Barbieri R L, Osathanondh R, Ryan K J
出版信息
Obstet Gynecol. 1981 Jun;57(6):722-4.
PMID:6940056
Abstract
In human corpus luteum (CL) microsomes, danazol inhibited 3 beta-hydroxysteroid dehydrogenase, 17,20-lyase, 17 alpha-hydroxylase, and 17 beta-hydroxysteroid dehydrogenase enzymes. Danazol did not inhibit aromatase. The observation that danazol can directly inhibit multiple enzymes of CL steroidogenesis may provide a molecular basis for explaining previous reports that danazol inhibits CL steroidogenesis in the monkey in vivo.
摘要
在人黄体（CL）微粒体中，达那唑抑制3β-羟基类固醇脱氢酶、17,20-裂解酶、17α-羟化酶和17β-羟基类固醇脱氢酶。达那唑不抑制芳香化酶。达那唑可直接抑制黄体类固醇生成的多种酶这一观察结果，可能为解释先前关于达那唑在体内抑制猴黄体类固醇生成的报道提供分子基础。
Zotero 插件