Henderson K M, Tsang B K
Fertil Steril. 1980 May;33(5):550-6. doi: 10.1016/s0015-0282(16)44722-9.
Danazol inhibited chorionic gonadotropin-stimulated progesterone production by pregnant rat luteal cells in vitro in a dose-dependent fashion. Spectral studies indicated that the inhibition was a consequence of danazol's interfering with the functioning of mitochondrial cytochrome P-450, an essential component of the enzyme system involved in progesterone biosynthesis. Danazol also suppressed luteal function in vivo, serum levels of progesterone being reduced by 50% to 70% when danazol (50 mg/kg) was administered thrice daily to rats from days 10 to 15 of pregnancy. Since danazol (30 microM) also inhibited progesterone production by human luteal cells in vitro and was dominant to the luteotrophic action of chorionic gonadotropin, it is suggested that danazol may have some potential as an interceptive agent in humans.
达那唑在体外以剂量依赖的方式抑制孕鼠黄体细胞中绒毛膜促性腺激素刺激的孕酮生成。光谱研究表明，这种抑制作用是达那唑干扰线粒体细胞色素P - 450功能的结果，细胞色素P - 450是参与孕酮生物合成的酶系统的重要组成部分。达那唑在体内也抑制黄体功能，当从妊娠第10天至15天每天给大鼠三次注射达那唑（50毫克/千克）时，血清孕酮水平降低50%至70%。由于达那唑（30微摩尔）在体外也抑制人黄体细胞的孕酮生成，并且对绒毛膜促性腺激素的促黄体作用具有优势，因此提示达那唑可能具有作为人类截流剂的一些潜力。
