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人体小肠杯状细胞的铁排泄。铁稳态中的一种额外调节机制?

Iron excretion from the goblet cells of the small intestine in man. An additional regulatory mechanism in iron homeostasis?

作者信息

Refsum S B, Schreiner B

出版信息

Scand J Gastroenterol. 1980;15(8):1013-20. doi: 10.3109/00365528009181806.

DOI:10.3109/00365528009181806
PMID:6940236
Abstract

Iron-excreting goblet cells were observed by chance in a patient with myelogenic leukaemia. Duodenal and jejunal biopsies from patients with a wide spectrum of disorders have therefore been examined retrospectively after staining with Perl's iron method. Thirty-seven of the patients had iron-excreting goblet cells. The presence of iron has been confirmed by X-ray microanalysis and by electron microscopic histochemistry. In addition to iron-excreting goblet cells, most of these patients had iron-containing macrophages in lamina propria. This may indicate that the two types of cells co-operate in the excretion process. It is suggested that iron excretion may be part of the common iron balance mechanism.

摘要

在一名骨髓性白血病患者中偶然观察到了排铁杯状细胞。因此,我们用珀耳铁染色法对患有多种疾病的患者的十二指肠和空肠活检组织进行了回顾性检查。其中37名患者有排铁杯状细胞。通过X射线微量分析和电子显微镜组织化学证实了铁的存在。除了排铁杯状细胞外,这些患者中的大多数在固有层还有含铁巨噬细胞。这可能表明这两种细胞在排泄过程中相互协作。有人提出,铁排泄可能是常见铁平衡机制的一部分。

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1
Iron excretion from the goblet cells of the small intestine in man. An additional regulatory mechanism in iron homeostasis?人体小肠杯状细胞的铁排泄。铁稳态中的一种额外调节机制?
Scand J Gastroenterol. 1980;15(8):1013-20. doi: 10.3109/00365528009181806.
2
[Participation of the goblet cells of the small intestine in the excretion of Fe, Zn and Pb cations].[小肠杯状细胞在铁、锌和铅阳离子排泄中的作用]
Tsitologiia. 1987 Nov;29(11):1284-9.
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J Anim Sci. 2016 Dec;94(12):5219-5229. doi: 10.2527/jas.2016-0713.
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Ultrastructural aspects of the small intestinal lead toxicology. Part II. The small intestine goblet cells of rats during lead poisoning.小肠铅中毒的超微结构特征。第二部分。铅中毒大鼠的小肠杯状细胞
Exp Pathol. 1988;35(2):93-100. doi: 10.1016/s0232-1513(88)80103-8.
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Iron absorption by small intestine of chickens.鸡小肠对铁的吸收
Biol Trace Elem Res. 1993 Jan;36(1):7-14. doi: 10.1007/BF02783775.
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[Hepcidin, the negative regulator of iron absorbtion].[铁调素,铁吸收的负调节因子]
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[ELECTRON MICROSCOPE IMAGE OF THE INTESTINAL MUCOSA IN MAN AFTER ADMINISTRATION OF DIVALENT IRON].[给予二价铁后人体小肠黏膜的电子显微镜图像]
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Effect of varying iron stores on site of intestinal absorption of cobalt and iron.不同铁储备对钴和铁肠道吸收部位的影响。
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Mechanisms of iron absorption and transport in neonatal rat intestine.新生大鼠肠道中铁吸收与转运的机制
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Biol Trace Elem Res. 1991 May;29(2):77-92. doi: 10.1007/BF03032686.