Evans J J, Bozdech M J
Arch Intern Med. 1981 May;141(6):786-7.
Hypokalemia has been noted as a frequent complication of acute leukemia. To our knowledge, an association of this electrolyte disturbance with chronic myelogenous leukemia (CML), not in blast crisis, has never been reported. We report a unique case of hypokalemia that complicated the clinical course of a patient with nonblastic CML. The pathogenesis of the hypokalemia was shown to be inappropriate hyperkaluresis, which appeared to be related to lysozymuria and a large tumor burden. We discuss the pathogenesis of hypokalemia in leukemia. We think that the unusual features associated with CML in this case make a large tumor burden their most likely underlying cause. This may help explain the still confusing and unresolved relationship between lysozymuria and potassium wasting in leukemia.
低钾血症是急性白血病常见的并发症。据我们所知，这种电解质紊乱与非急变期慢性粒细胞白血病（CML）的关联从未有过报道。我们报告了一例独特的低钾血症病例，该病例使一名非急变期CML患者的临床病程复杂化。低钾血症的发病机制被证明是不适当的高尿钾，这似乎与溶菌酶尿症和巨大肿瘤负荷有关。我们讨论了白血病中低钾血症的发病机制。我们认为，该病例中与CML相关的异常特征使其最可能的潜在原因是巨大肿瘤负荷。这可能有助于解释白血病中溶菌酶尿症与钾消耗之间仍然令人困惑且未解决的关系。
