Ledoux F, Bergerat J P, Vetter J M, Lang J M, Oberling F
Arch Intern Med. 1978 Aug;138(8):1287-90.
A 48-year-old man suffering from acute myeloid leukemia presented a hypokalemia that persisted almost constantly during 18 months despite total hematological remission. The renal investigation demonstrated a hypokalemic nephropathy with an impairment of urinary concentrating function. Light and electron microscopy showed renal lesions related to potassium depletion. We did not observe specific lesions explaining the renal potassium wasting. Metabolic studies showed persistent hyperkaluresis, which appeared to be the main kaliopenic factor. We also found hypomagnesemia and changes of the renin-aldosterone system. We observed a hyperreninism, probably due to hypokalemia and a slight hyperaldosteronism, which could have been one of the kaluretic agents.
一名48岁的急性髓系白血病男性患者出现低钾血症，尽管血液学完全缓解，但在18个月内几乎持续存在。肾脏检查显示为低钾性肾病，伴有尿浓缩功能损害。光镜和电镜检查显示肾脏病变与钾缺乏有关。我们未观察到解释肾脏钾流失的特异性病变。代谢研究显示持续的高钾尿症，这似乎是主要的低钾因素。我们还发现了低镁血症以及肾素 - 醛固酮系统的变化。我们观察到高肾素血症，可能是由于低钾血症引起的，还有轻度醛固酮增多症，这可能是钾尿剂之一。
