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RFM/Un小鼠髓性白血病发育的电子自旋共振研究

ESR study of development of RFM/Un murine myeloid leukaemia.

作者信息

Dodd N J, Silcock J M

出版信息

Br J Cancer. 1978 Nov;38(5):612-8. doi: 10.1038/bjc.1978.257.

Abstract

The blood, spleen and liver of RFM/Un mice were examined by means of electron spin resonance (ESR) throughout the course of myeloid leukaemia induced by i.v. injection of leukaemic spleen cells. Marked changes in the concentration of iron transferrin and caeruloplasmin were observed in the blood 1 day after injection. As the disease progressed, changes occurred in the concentrations of the ascorbyl radical and of paramagnetic metal complexes in both spleen and liver. These changes are compared with those induced in RF/J mice injected with normal and leukaemic spleen cells from RFM/Un mice.

摘要

通过电子自旋共振(ESR)对RFM/Un小鼠在静脉注射白血病脾细胞诱导髓性白血病的整个过程中的血液、脾脏和肝脏进行了检查。注射后1天在血液中观察到铁转铁蛋白和铜蓝蛋白浓度的显著变化。随着疾病进展,脾脏和肝脏中的抗坏血酸自由基和顺磁性金属络合物浓度均发生了变化。将这些变化与注射来自RFM/Un小鼠的正常和白血病脾细胞的RF/J小鼠所诱导的变化进行了比较。

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本文引用的文献

1
Electron spin resonance and Mössbauer effect studies of ferritin.
Biochim Biophys Acta. 1971 Jan 19;229(1):68-74. doi: 10.1016/0005-2795(71)90319-9.
3
Some EPR signals in tumour tissue.肿瘤组织中的一些电子顺磁共振信号。
Br J Cancer. 1973 Sep;28(3):257-62. doi: 10.1038/bjc.1973.145.
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Electron spin resonance in biological tissues.生物组织中的电子自旋共振
Phys Med Biol. 1969 Jul;14(3):373-96. doi: 10.1088/0031-9155/14/3/201.

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