牛磺胆酸、甘氨胆酸和溶血卵磷脂在大鼠实验性应激性溃疡中的作用。
The role of taurocholic acid, glycocholic acid and lysolecithin in experimental stress ulcer in the rat.
作者信息
Clémençon G H, Finger J, Fehr H F
出版信息
Scand J Gastroenterol Suppl. 1981;67:137-40.
PMID:6941393
Abstract
The stress ulcer formation is enhanced significantly in rats operated with pyloro-jejunostomy and Roux-en-Y anastomosis by taurocholic acid or a mixture of taurocholic and glycocholic acid. However, the incidence of stress ulcers is significantly reduced by adding lysolecithin to the drinking solution containing these bile acids in the same concentration, though lysolecithin alone induces significantly more stress ulcers than tap water in rats with the same operation submitted to immobilisation stress.
摘要
通过牛磺胆酸或牛磺胆酸与甘氨胆酸的混合物进行幽门空肠吻合术和Roux-en-Y吻合术的大鼠，应激性溃疡的形成显著增强。然而，在含有相同浓度这些胆汁酸的饮水中添加溶血卵磷脂，可显著降低应激性溃疡的发生率，尽管在遭受固定应激的相同手术大鼠中，单独使用溶血卵磷脂比自来水诱导出更多的应激性溃疡。
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