Fehr H F, Aebi M, Finger J, Clémençon G H
Scand J Gastroenterol Suppl. 1981;67:187-9.
We present an operation model in rats, which according to our opinion prevents duodenogastric reflux effectively. The duodenum is divided distally from the pylorus and a pyloro-jejunostomy performed combined with a Roux-en-Y anastomosis. Rats operated this way and submitted to restraint stress developed significantly less stress lesions than operated control under same conditions. However, operated rats submitted to the operation and offered a 5 mMol/l drinking solution of crude taurocholic acid during 20 days before submitted to stress had significantly more stress lesions than operated animals with tap water before restraint stress.
我们提出了一种大鼠手术模型，据我们认为该模型可有效防止十二指肠-胃反流。将十二指肠从幽门远端进行分割，并进行幽门-空肠吻合术，同时结合Roux-en-Y吻合术。以这种方式手术并承受束缚应激的大鼠，与在相同条件下的手术对照组相比，所产生的应激损伤明显更少。然而，在承受应激前20天接受手术并饮用5毫摩尔/升牛磺胆酸粗溶液的手术大鼠，与在束缚应激前饮用自来水的手术动物相比，其应激损伤明显更多。
