Lawson H H
Scand J Gastroenterol Suppl. 1981;67:141-7.
Fifteen human antrectomy specimens removed for prepyloric ulceration have been examined using the 'Swiss roll' technique. A limited amount of severe chronic gastritis has been shown to be present on the lesser or greater curvature in 9 cases, depending on the position of the ulcer. Gastritis persisted in spite of histological healing of the ulcer in a further 6 cases. This is presented as evidence to support the view that limited severe gastritis may be of importance in the pathogenesis of prepyloric ulceration. An hypothesis is advanced suggesting that acid hypersecretion leading to ulceration within the area of gastritis may be an additional second factor of importance in some cases, and that the distance of the ulcer from the duodenum would depend on the level of acid hypersecretion.
已使用“瑞士卷”技术对15例因幽门管溃疡而切除的人胃窦标本进行了检查。结果显示，9例患者的胃小弯或大弯处存在少量重度慢性胃炎，具体取决于溃疡的位置。在另外6例患者中，尽管溃疡已实现组织学愈合，但胃炎仍持续存在。这一发现作为证据支持了以下观点：局限性重度胃炎可能在幽门管溃疡的发病机制中起重要作用。本文提出了一种假说，认为在某些情况下，胃酸分泌过多导致胃炎区域内发生溃疡可能是另一个重要的次要因素，并且溃疡与十二指肠的距离取决于胃酸分泌过多的程度。
