Lawson H H
Scand J Gastroenterol Suppl. 1981;67:91-8.
Using dogs as the experimental model, procedures were carried out to expose the gastric mucosa to bile, pancreatic juice or a mixture of bile and pancreatic juice. Each dog acted as its own control. Strips of mucosa from the whole length of the stomach were used and "Swiss roll" preparations were made. It was found that the maximum degree of gastritis occurred after exposure to both bile and pancreatic juice. Whole thickness patches of gastric mucosa with an intact blood supply were exteriorized on the anterior abdominal wall in a separate study. When these explants, now affected by severe chronic gastritis were reimplanted into the stomach and were in contact with gastric contents, ulceration developed. It was concluded therefore that areas of chronic gastritis were in fact susceptible to ulceration.
以狗作为实验模型，开展了将胃黏膜暴露于胆汁、胰液或胆汁与胰液混合物的实验。每只狗自身作为对照。使用了取自整个胃长度的黏膜条制作“瑞士卷”标本。结果发现，暴露于胆汁和胰液后胃炎程度最为严重。在另一项研究中，将具有完整血供的全层胃黏膜片外置在前腹壁。当这些现已受到严重慢性胃炎影响的外植体重新植入胃并与胃内容物接触时，发生了溃疡。因此得出结论，慢性胃炎区域实际上易发生溃疡。
