Krohn K
Scand J Infect Dis Suppl. 1981;26:101-3.
In a double-blind randomized trial the effect of a single oral tinidazole dose of 2 g, given pre-operatively, on the infection rate was assessed in 210 patients undergoing first trimester abortion by vacuum aspiration (VA) and compared to placebo medication. Anaerobic and facultative anaerobic bacteria were the predominant organisms isolated from the cervix. Six patients in the tinidazole group and 11 from the control group developed a postoperative pelvic infection necessitating antibiotic therapy. In 2 patients, one in each group, hospitalization was necessary. This study indicated that identification of the bacteria present in the cervix before VA does not make it possible to predict the likelihood of the postoperative pelvic infection. Tinidazole administration preoperatively seems to reduce the postoperative pelvic infection rate after VA.
在一项双盲随机试验中，对210例接受孕早期人工流产负压吸引术（VA）的患者，评估术前单次口服2g替硝唑对感染率的影响，并与安慰剂治疗进行比较。从宫颈分离出的主要微生物是厌氧菌和兼性厌氧菌。替硝唑组有6例患者，对照组有11例患者发生术后盆腔感染，需要抗生素治疗。每组各有1例患者需要住院治疗。这项研究表明，在VA术前识别宫颈中存在的细菌并不能预测术后盆腔感染的可能性。术前给予替硝唑似乎可以降低VA术后盆腔感染率。
