Lundberg C, Lönnroth J, Marklund G, Nord C E
Scand J Infect Dis Suppl. 1981;26:130-4.
Sixteen patients with primary or secondary anaerobic infections of the maxillary sinus, mouth and throat were treated with tinidazole. The peak plasma concentration in eight patients given 2 g tinidazole initially followed by 1 g daily on the 5 subsequent days varied between 15 and 48 microgram/ml the first day and were only slightly lower during the following days. The mixed saliva/plasma concentration ratios ranged between 0.2 and 1.8 with a mean value of 0.85. In eight patients with anginose infectious mononucleosis, a rapid improvement was observed after the onset of treatment. Normal body temperature and well-being was restored within 3 to 5 days. No bacteria considered to be involved in the infection of the throat were isolated from these patients, and it, therefore, seems unlikely that the clinical benefit is attributable only to antibacterial activity of tinidazole. Anaerobic infections in five patients with purulent maxillary sinusitis, two patients with acute exacerbation of atrophic pharyngitis and one patient with a necrotic ulcer of the tongue, were treated successfully with tinidazole.
16例患有上颌窦、口腔和咽喉原发性或继发性厌氧菌感染的患者接受了替硝唑治疗。8例患者初始给予2g替硝唑，随后5天每天给予1g，第一天血浆峰值浓度在15至48微克/毫升之间，随后几天仅略有降低。混合唾液/血浆浓度比在0.2至1.8之间，平均值为0.85。8例患有咽峡炎传染性单核细胞增多症的患者在治疗开始后病情迅速改善。3至5天内恢复了正常体温和健康状态。从这些患者中未分离出被认为与咽喉感染有关的细菌，因此，临床获益似乎不太可能仅归因于替硝唑的抗菌活性。5例化脓性上颌窦炎、2例萎缩性咽炎急性加重患者和1例舌部坏死性溃疡患者的厌氧菌感染经替硝唑治疗成功。
