García J M, Molina J, Herrera J
Rev Esp Fisiol. 1978 Jun;34(2):145-8.
The effect of oral hypoglycaemic drugs, derivatives of sulphonylurea, upon urease has been studied. These compounds, structurally connected to urea, produce a competitive inhibition of enzyme activity with respect to substrate. Glutathioné (reduced form) and cysteine prevent inactivation of enzyme by sulphonylurea, whereas-oxidated glutathione and cysteine do not. The same phenomenon occurs in enzyme preparations inhibited by p-hydroxymercuribenzoate. The role of sulfhydryl groups in the formation of enzyme-substrate complex is discussed.
已经研究了口服降糖药（磺酰脲衍生物）对脲酶的作用。这些与尿素在结构上相关的化合物，对底物而言会产生酶活性的竞争性抑制。谷胱甘肽（还原型）和半胱氨酸可防止磺酰脲使酶失活，而氧化型谷胱甘肽和半胱氨酸则不能。在对羟基汞苯甲酸抑制的酶制剂中也会出现同样的现象。文中讨论了巯基在酶 - 底物复合物形成中的作用。
