Lambertenghi-Deliliers G, Polli N, Pozzoli E, Nava M, Soligo D
Tumori. 1981 Mar-Apr;67(2):151-7. doi: 10.1177/030089168106700213.
Bone marrow and peripheral blood samples of patients affected by hematologic disorders involving the megakaryocytic line were examined at the electron microscope. While in idiopathic thrombocytopenic purpura the megakaryocytes appeared almost normal, in primary thrombocythemia there were various ultrastructural alterations interpreted as a counterpart of ineffective thrombocytopoiesis. In one patient with blastic chronic myeloid leukemia and in another with acute megakaryoblastic leukemia, the electron microscope study was very useful in the identification of immature megakaryocytes. In fact, analysis of various ultrastructural parameters allowed some blast cells to be attributed to the megakaryocytic series. Furthermore, platelet demarcation system abnormalities and alterations of the circulating thrombocytes confirm the hypothesis that there is a block in megakaryocytic maturation.
对患有涉及巨核细胞系的血液系统疾病的患者的骨髓和外周血样本进行了电子显微镜检查。在特发性血小板减少性紫癜中，巨核细胞几乎看起来正常，而在原发性血小板增多症中，有各种超微结构改变，这些改变被解释为无效血小板生成的对应表现。在一名慢性粒细胞白血病急变期患者和另一名急性巨核细胞白血病患者中，电子显微镜研究对于识别未成熟巨核细胞非常有用。事实上，对各种超微结构参数的分析使得一些原始细胞被归为巨核细胞系列。此外，血小板分界系统异常和循环血小板的改变证实了存在巨核细胞成熟受阻这一假说。
