胸苷标记指数在成人急性白血病中缺乏预后价值。
Lack of prognostic value of the thymidine-labelling index in adult acute leukaemia.
作者信息
Sewell R L, Lister T A, Johnson S A, Crowther D
出版信息
Br J Cancer. 1981 Jul;44(1):55-62. doi: 10.1038/bjc.1981.147.
A study has been made of the thymidine labelling index (TLI) of marrow blast cells in 201 adults with untreated acute leukaemia. There was no significant difference between the TLI in 172 patients with acute myeloblastic leukaemia and 29 patients with acute lymphoblastic leukaemia. The TLI did not correlate with the age, sex, peripheral-blood or marrow blast-cell count, or the platelet count at presentation. In neither acute myeloblastic leukaemia nor acute lymphoblastic leukaemia was there any correlation between the TLI and the response to the initial therapy, the duration of the first complete remission or survival.
对201例未经治疗的急性白血病成年患者的骨髓原始细胞的胸腺嘧啶核苷标记指数（TLI）进行了研究。172例急性髓细胞白血病患者和29例急性淋巴细胞白血病患者的TLI之间无显著差异。TLI与年龄、性别、外周血或骨髓原始细胞计数，或初诊时的血小板计数均无相关性。在急性髓细胞白血病和急性淋巴细胞白血病中，TLI与初始治疗反应、首次完全缓解持续时间或生存期均无相关性。
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