Monteil R A
J Biol Buccale. 1981 Jun;9(2):109-28.
Fordyce spots are sebaceous glands without hair follicles, most often located under the epithelium of the cheek and free lip border. These glands, present in 80 to 95% of adults, according to the localization, cannot be considered as ectopic. Along the same lines, these spots are neither a disease, a lesion or an adenoma. These glands are acino-tubular and distributed in clusters. They are connected to the covering epithelium by a duct with a keratinizing stratified epithelium. By analog to what has been done in the skin, the acinous cells can be artificially classified in three groups: basal germinative cells partially differentiated intermediary cells and totally differentiated preductal cells. With PAS-Mac Manus, the peripheral cells are characterized by a reduced cytoplasm, the scarcity of organelles, as well as the presence of tonofilaments and desmosomes. The intermediary cells have a low nucleus-cytoplasm ratio. While keeping their epidermal characters, they become rich in lipid droplets of variable sizes and are closely related to numerous mitochondria. The cytoplasm of completely differentiated cells, with unrecognizable organelles, are invaded by large lipid globules. In the periacinous connective tissues, fenestrated capillaries are observed.
福代斯斑是没有毛囊的皮脂腺，最常见于脸颊上皮和游离唇缘下方。根据其位置，这些腺体存在于80%至95%的成年人中，不能被视为异位。同样，这些斑点既不是疾病、病变也不是腺瘤。这些腺体是腺管状的，呈簇状分布。它们通过一个具有角化复层上皮的导管与覆盖上皮相连。类似于在皮肤中所做的，腺泡细胞可人为地分为三组：基底生发细胞、部分分化的中间细胞和完全分化的导管前细胞。用PAS - Mac Manus染色法，周边细胞的特征是细胞质减少、细胞器稀少，以及存在张力丝和桥粒。中间细胞的核质比低。它们在保持表皮特征的同时，富含大小不一的脂滴，并且与大量线粒体密切相关。完全分化细胞的细胞质中细胞器难以辨认，被大的脂球所占据。在腺泡周围的结缔组织中，可见有窗孔的毛细血管。
