Smith G B, Schoenewaldt E F
J Pharm Sci. 1981 Mar;70(3):272-6. doi: 10.1002/jps.2600700312.
The stability of N-formimidoylthienamycin in aqueous solution at 25 and 40 degrees was determined. In pH 5-8 nonnucleophilic inert buffers, pseudo-first-order ring opening was observed with dilute solutions (1 or 2 mg/ml initially). At higher initial concentrations, a second-order reaction also was evident. The rate data were compared with literature data for various cephalosporins and penicillins.
测定了N-甲脒硫霉素在25℃和40℃水溶液中的稳定性。在pH 5 - 8的非亲核惰性缓冲液中，对于稀溶液（初始浓度为1或2毫克/毫升）观察到拟一级开环反应。在较高的初始浓度下，二级反应也很明显。将速率数据与各种头孢菌素和青霉素的文献数据进行了比较。
