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1
Imipenem susceptibility testing with a commercially prepared dry-format microdilution tray.使用市售干式微量稀释板进行亚胺培南药敏试验。
J Clin Microbiol. 1986 Jun;23(6):1134-5. doi: 10.1128/jcm.23.6.1134-1135.1986.
2
Comparison of sensititre broth microdilution and agar dilution susceptibility testing techniques for meropenem to determine accuracy, reproducibility, and predictive values.比较美罗培南的微量肉汤稀释法和琼脂稀释法药敏试验技术以确定准确性、重复性和预测值。
J Clin Microbiol. 1994 Sep;32(9):2204-7. doi: 10.1128/jcm.32.9.2204-2207.1994.
3
Failure of quality control measures to prevent reporting of false resistance to imipenem, resulting in a pseudo-outbreak of imipenem-resistant Pseudomonas aeruginosa.质量控制措施未能防止对亚胺培南的假耐药报告，导致耐亚胺培南铜绿假单胞菌的假性暴发。
J Clin Microbiol. 1998 Feb;36(2):595-7. doi: 10.1128/JCM.36.2.595-597.1998.
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Antimicrobial susceptibility testing of carbapenems: multicenter validity testing and accuracy levels of five antimicrobial test methods for detecting resistance in Enterobacteriaceae and Pseudomonas aeruginosa isolates.碳青霉烯类抗菌药物敏感性试验：五种抗菌检测方法检测肠杆菌科细菌和铜绿假单胞菌分离株耐药性的多中心有效性测试及准确性水平
J Clin Microbiol. 2003 Jan;41(1):351-8. doi: 10.1128/JCM.41.1.351-358.2003.
5
Stability of imipenem in Mueller-Hinton agar stored at 4 degrees C.亚胺培南在4℃保存的穆勒-欣顿琼脂中的稳定性。
Antimicrob Agents Chemother. 1985 Nov;28(5):711-2. doi: 10.1128/AAC.28.5.711.
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Effect of zinc concentration in Mueller-Hinton agar on susceptibility of Pseudomonas aeruginosa to imipenem.穆勒-欣顿琼脂中锌浓度对铜绿假单胞菌对亚胺培南敏感性的影响。
J Clin Microbiol. 1997 Apr;35(4):1027-9. doi: 10.1128/jcm.35.4.1027-1029.1997.
7
Activity of meropenem against imipenem-resistant bacteria and selection in vitro of carbapenem-resistant Enterobacteriaceae.
Eur J Clin Microbiol Infect Dis. 1992 Dec;11(12):1186-91. doi: 10.1007/BF01961143.
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Wide variability in Pseudomonas aeruginosa aminoglycoside results among seven susceptibility testing procedures.七种药敏试验方法检测铜绿假单胞菌氨基糖苷类药物结果存在广泛差异。
J Clin Microbiol. 1989 Oct;27(10):2277-85. doi: 10.1128/jcm.27.10.2277-2285.1989.
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Tentative interpretive criteria for in vitro antibacterial susceptibility testing with imipenem.亚胺培南体外抗菌药敏试验的暂行解释标准。
J Clin Microbiol. 1986 Mar;23(3):421-4. doi: 10.1128/jcm.23.3.421-424.1986.
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Antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci, cefotaxime-resistant Enterobacteriaceae and Pseudomonas aeruginosa.
J Antimicrob Chemother. 1986 Dec;18 Suppl E:27-33. doi: 10.1093/jac/18.supplement_e.27.

引用本文的文献

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Validation of the automated reading and incubation system with Sensititre plates for antimicrobial susceptibility testing.使用Sensititre平板的自动读取和孵育系统进行抗菌药物敏感性测试的验证。
J Clin Microbiol. 2003 May;41(5):1951-6. doi: 10.1128/JCM.41.5.1951-1956.2003.
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Discrepancies in susceptibility test results for imipenem employing different in vitro test methods and DIN 58,940 breakpoints.
Eur J Clin Microbiol Infect Dis. 1995 Jan;14(1):11-7. doi: 10.1007/BF02112612.
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Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.亚胺培南/西司他丁。对其抗菌活性、药代动力学特性及治疗效果的综述。
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False resistance to imipenem with a microdilution susceptibility testing system.使用微量稀释药敏试验系统时对亚胺培南的假耐药性。
J Clin Microbiol. 1991 Apr;29(4):827-9. doi: 10.1128/jcm.29.4.827-829.1991.
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Pseudoresistance of Pseudomonas aeruginosa resulting from degradation of imipenem in an automated susceptibility testing system with predried panels.在使用预干燥药敏板的自动化药敏检测系统中，因亚胺培南降解导致铜绿假单胞菌出现假耐药。
J Clin Microbiol. 1991 Feb;29(2):398-400. doi: 10.1128/jcm.29.2.398-400.1991.

本文引用的文献

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Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.N-甲酰亚胺硫霉素对革兰氏阳性和革兰氏阴性需氧及厌氧菌的体外比较活性及其β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1982 Jan;21(1):180-7. doi: 10.1128/AAC.21.1.180.
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Susceptibilities of anaerobic bacteria to N-formimidoyl thienamycin (MK0787) and to other antibiotics.厌氧菌对N-甲酰亚胺基硫霉素（MK0787）及其他抗生素的敏感性。
Antimicrob Agents Chemother. 1982 Jun;21(6):1016-22. doi: 10.1128/AAC.21.6.1016.
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Activity of N-formimidoyl thienamycin and cephalosporins against isolates from nosocomially acquired bacteremia.N-甲酰亚胺硫霉素和头孢菌素对医院获得性菌血症分离株的活性。
Antimicrob Agents Chemother. 1982 Mar;21(3):509-12. doi: 10.1128/AAC.21.3.509.
4
Stability of N-formimidoylthienamycin in aqueous solution.N-甲酰亚胺硫霉素在水溶液中的稳定性。
J Pharm Sci. 1981 Mar;70(3):272-6. doi: 10.1002/jps.2600700312.
5
A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives.N-甲酰亚胺基硫霉素（MK0787）与其他近期研发的β-内酰胺衍生物抗菌活性的比较。
Antimicrob Agents Chemother. 1982 Aug;22(2):302-7. doi: 10.1128/AAC.22.2.302.
6
Bioactivity of imipenem as a function of medium, time, and temperature.亚胺培南的生物活性与培养基、时间和温度的关系。
Antimicrob Agents Chemother. 1984 Jun;25(6):781-2. doi: 10.1128/AAC.25.6.781.
7
Comparative in-vitro activity of MK0787 (N-formimidoyl thienamycin) against 540 blood culture isolates.
J Antimicrob Chemother. 1982 Mar;9(3):183-94. doi: 10.1093/jac/9.3.183.
8
Automated reading of MIC microdilution trays containing fluorogenic enzyme substrates with the Sensititre Autoreader.使用Sensititre自动读数仪对含有荧光酶底物的MIC微量稀释板进行自动读数。
J Clin Microbiol. 1985 Aug;22(2):187-91. doi: 10.1128/jcm.22.2.187-191.1985.
9
Effects of storage temperature and pH on the stability of eleven beta-lactam antibiotics in MIC trays.储存温度和pH值对药敏试验板中11种β-内酰胺类抗生素稳定性的影响
J Clin Microbiol. 1985 Mar;21(3):366-70. doi: 10.1128/jcm.21.3.366-370.1985.

使用市售干式微量稀释板进行亚胺培南药敏试验。

Imipenem susceptibility testing with a commercially prepared dry-format microdilution tray.

作者信息

Staneck J L

出版信息

J Clin Microbiol. 1986 Jun;23(6):1134-5. doi: 10.1128/jcm.23.6.1134-1135.1986.

DOI:10.1128/jcm.23.6.1134-1135.1986
PMID:3086377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC268808/
Abstract

MICs of imipenem, concurrently generated in commercially prepared microdilution trays containing predried antibiotic dilutions (Sensititre), and in a standard agar dilution assay (as recommended by the National Committee for Clinical Laboratory Standards, Villanova, Pa.), were within +/- 1 twofold dilution for 94% of 226 bacterial isolates. Imipenem biological activity remained stable over 5 months of tray storage at room temperature against Pseudomonas aeruginosa ATCC 27853. Activity of imipenem was shown by microdilution testing with 890 clinical isolates to be high, with only 4% of isolates having MICs of greater than or equal to 16 micrograms/ml (in vitro resistance).

摘要

亚胺培南的最低抑菌浓度（MIC），同时在含有预干燥抗生素稀释液的商业制备微量稀释板（Sensititre）中以及在标准琼脂稀释试验（按照宾夕法尼亚州维拉诺瓦市临床实验室标准委员会的推荐）中测定，对于226株细菌分离株中的94%，二者结果在±1倍稀释范围内。在室温下将微量稀释板保存5个月期间，亚胺培南对铜绿假单胞菌ATCC 27853的生物活性保持稳定。通过对890株临床分离株进行微量稀释试验表明，亚胺培南的活性较高，只有4%的分离株的MIC大于或等于16微克/毫升（体外耐药）。