Friedlander E, Morrison A S
J Natl Cancer Inst. 1981 Aug;67(2):347-51.
Urinary excretion of six aromatic amine metabolites of tryptophan was compared between a group of 30 patients with bladder cancer and a group of 33 controls selected from the general population of the study area. Measurements were based on a single overnight urine specimen collected at home by each subject, without a "loading" does of L-tryptophan. For each metabolite, both the distribution and the mean amount excreted were nearly identical for cases and controls. The small cases-control differences in mean values were virtually unchanged by adjustment for age, sex, and smoking status. Generally, excretion levels were higher for females than for males. Excretion levels also tended to be higher for older than for younger subjects and for smokers compared to nonsmokers. However, most of these differences also were small.
在一组30名膀胱癌患者和一组从研究区域的普通人群中选取的33名对照者之间，比较了色氨酸的六种芳香胺代谢物的尿排泄情况。测量基于每个受试者在家中收集的一份过夜尿液样本，未给予L-色氨酸“负荷”剂量。对于每种代谢物，病例组和对照组的排泄分布及平均排泄量几乎相同。通过对年龄、性别和吸烟状况进行调整后，病例组和对照组在平均值上的微小差异实际上没有变化。一般来说，女性的排泄水平高于男性。排泄水平也往往在年长者中高于年轻者，吸烟者高于非吸烟者。然而，这些差异大多也很小。
