Wolf H, Brown R R, Nyholm K
Acta Vitaminol Enzymol. 1975;29(1-6):117-22.
Urinary excretion of metabolites of the kynurenine pathway before and after a loading dose of 2 g L-tryptophan was studied in 31 bladder cancer patients from the Copenhagen area. Only 2 patients (6 per cent) showed abnormal tryptophan metabolism, and both patients excreted increased amounts of only 3-hydroxykynurenine after a loading dose of 2 g L-tryptophan. The percentage of bladder cancer patients with abnormal tryptophan metabolism is compared with the percentage found in other parts of the world. It is suggested that these findings may indicate that tryptophan metabolites do not play a major role in the genesis of bladder cancer among bladder cancer patients from the Copenhagen area. Other etiologic factors should be looked for.
在来自哥本哈根地区的31名膀胱癌患者中，研究了2克L-色氨酸负荷剂量前后犬尿氨酸途径代谢产物的尿排泄情况。仅2名患者（6%）显示色氨酸代谢异常，且这两名患者在2克L-色氨酸负荷剂量后仅3-羟基犬尿氨酸排泄量增加。将色氨酸代谢异常的膀胱癌患者百分比与世界其他地区的发现百分比进行了比较。有人认为，这些发现可能表明色氨酸代谢产物在哥本哈根地区膀胱癌患者的膀胱癌发生中不起主要作用。应寻找其他病因因素。
