Kamaya H, Suezaki Y, Ueda I, Eyring H
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3572-5. doi: 10.1073/pnas.78.6.3572.
Anesthetics expand cell membranes, and high pressures (about 10-15 MPa) antagonize the anesthetic action. It is also known that inhalation anesthetics expand elastomer membranes. The mechanism of pressure antagonism of anesthetic action on membrane expansion was investigated in the present study with Silastic membranes. Halothane increased the length of Silastic membrane (0.14% per kPa), with an accompanying decrease of Young's modulus (3.7.10(5) Newton/m2 per kPa). High pressure decreased the length of the membrane and increased Young's modulus. The magnitudes of the pressure effect on the length and Young's modulus of the Silastic membrane in the presence of the anesthetic were not identical with those observed in the absence of the anesthetic. In the presence of halothane at pressures common to clinical applications, the bulk modulus of the membrane decreased about 4.6-4.0%. These results suggest that the effects of pressure and anesthetic upon the elastomer may not be completely independent of each other.
麻醉剂可使细胞膜扩张，而高压（约10 - 15兆帕）可拮抗麻醉作用。另外，已知吸入性麻醉剂可使弹性体膜扩张。本研究使用硅橡胶膜对麻醉作用于膜扩张的压力拮抗机制进行了研究。氟烷可增加硅橡胶膜的长度（每千帕增加0.14%），同时杨氏模量降低（每千帕降低3.7×10⁵牛顿/平方米）。高压可使膜的长度缩短，杨氏模量增加。在有麻醉剂存在的情况下，压力对硅橡胶膜长度和杨氏模量的影响程度与无麻醉剂时观察到的情况不同。在临床应用的常见压力下，存在氟烷时，膜的体积模量降低约4.6 - 4.0%。这些结果表明，压力和麻醉剂对弹性体的影响可能并非完全相互独立。
