垂体及其他器官中的成脂因子和抗成脂因子。
Adipogenic and anti-adipogenic factors in the pituitary and other organs.
作者信息
Hayashi I, Nixon T, Morikawa M, Green H
出版信息
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3969-72. doi: 10.1073/pnas.78.6.3969.
Adipose conversion of cultured 3T3 cells is known to depend on an adipogenic factor present in serum. In the presence of this factor, extracts of different organs were found to inhibit the adipose conversion. The most active extracts were derived from brain, uterus, and pituitary, but other organs also possessed appreciable activity. Fibroblast growth factor partially purified from both brain and pituitary was much more active in suppressing adipose conversion than were crude extracts of the corresponding organs. Purified platelet-derived growth factor was also an effective inhibitor. Of all the tissue extracts tested, only pituitary possessed, in addition to the inhibitory activity, an adipogenic factor similar to that demonstrated previously in serum. This was revealed at concentrations of extract too low for the inhibitory factor to be effective. Under these conditions the pituitary extract had a specific adipogenic activity orders of magnitude higher than that of serum. We suggest that the adipogenic factor of serum may originate in the pituitary.
已知培养的3T3细胞向脂肪细胞的转化依赖于血清中存在的一种脂肪生成因子。在这种因子存在的情况下，发现不同器官的提取物可抑制脂肪细胞的转化。活性最强的提取物来自脑、子宫和垂体，但其他器官也具有相当的活性。从脑和垂体中部分纯化得到的成纤维细胞生长因子在抑制脂肪细胞转化方面比相应器官的粗提物活性高得多。纯化的血小板衍生生长因子也是一种有效的抑制剂。在所有测试的组织提取物中，只有垂体除了具有抑制活性外，还具有一种与先前在血清中发现的类似的脂肪生成因子。这在提取物浓度过低以至于抑制因子无效的情况下得以显现。在这些条件下，垂体提取物的特定脂肪生成活性比血清高几个数量级。我们认为血清中的脂肪生成因子可能起源于垂体。
Zotero 插件