使用路径分析评估多因素性状的性别差异：在学习困难中的应用。

Assessment of sex differences for multifactorial traits using path analysis: application to learning difficulties.

作者信息

Rice J P, Nichols P L, Gottesman I I

出版信息

Psychiatry Res. 1981 Jun;4(3):301-12. doi: 10.1016/0165-1781(81)90032-9.

Abstract

A general model of multifactorial inheritance is described which allows for sex-specific transmission from parent to offspring, sex-specific correlations in the rearing environments of full siblings, and different prevalences for males and females for qualitative traits. Formulas for the correlations between several types of relatives are given in terms of an underlying path model, and a computer program, available upon request, is described. The model is applied to the Collaborative Perinatal Project sample of siblings and first cousins of children with learning difficulties. No sex differences were found either in transmission or in correlated sibling environments for learning difficulties. Evidence is given that the correlation between the rearing environments of siblings is negative, possibly due to differential allocation and family resources.

摘要

描述了一种多因素遗传的通用模型，该模型考虑了从父母到后代的性别特异性传递、同胞在养育环境中的性别特异性相关性以及定性性状在男性和女性中的不同患病率。根据一个潜在的路径模型给出了几种亲属类型之间相关性的公式，并描述了一个可根据要求提供的计算机程序。该模型应用于学习困难儿童的同胞和一级表亲的协作围产期项目样本。在学习困难的传递或相关同胞环境中均未发现性别差异。有证据表明，同胞养育环境之间的相关性为负，这可能是由于资源分配和家庭资源的差异所致。