Carp C
Med Interne. 1978 Jul-Sep;16(3):257-69.
To check up the value of atrial pacing (AP) in estimating the degree of healing in myocardial necrosis, an ECG study was carried out in 20 dogs with experimental myocardial infarction induced by ligation of the left descending coronary artery. The main ECG changes recorded after ligation i.e., Q waves in 14 animals (73%), S-T segment elevation in 14 (74%) and decrease of QRS voltage in 12 (63%), disappeared within a 7-day interval. Anesthesia with Nembutal 56--57 days after ligation and before AP application induced the occurrence of Q waves in 6 animals, S-T segment depression in 18 and T wave inversion in 12. AP during 20 minutes, at a heart rate of 200 beats/min, produced the appearance or the increase of S-T segment depression in 14 animals and T wave inversion in 12. These findings support the assumption that the AP stress test can be used for the evaluation of the necrosis degree in the healing stages of experimental myocardial infarction, but a correct interpretation of the ECG changes induced by AP should also take into account the previous abnormalities due to anesthesia.
为了检验心房起搏（AP）在评估心肌坏死愈合程度方面的价值，对20只通过结扎左冠状动脉前降支诱导实验性心肌梗死的犬进行了一项心电图研究。结扎后记录到的主要心电图变化，即14只动物（73%）出现Q波，14只（74%）出现ST段抬高，12只（63%）出现QRS电压降低，在7天内消失。在结扎后56 - 57天、应用AP之前用戊巴比妥麻醉，导致6只动物出现Q波，18只出现ST段压低，12只出现T波倒置。以200次/分钟的心率进行20分钟的AP，使14只动物出现或加重ST段压低，12只出现T波倒置。这些发现支持这样一种假设，即AP应激试验可用于评估实验性心肌梗死愈合阶段的坏死程度，但对AP诱导的心电图变化进行正确解读时，还应考虑到麻醉引起的先前异常情况。
