Bernard A, Bayle C, Caillou B, Lemerle J, Boumsell L
Nouv Presse Med. 1981;10(31):2571-3.
A 9-year-old child was found to have massive invasion of his bone marrow by malignant cells. Experienced pathologists were unable to determine on morphological grounds the nature of these cells, even after electron microscope study and multiple cytochemical staining of bone marrow smears. However, serological analysis of the cells showed that they displayed an antigen specific to cells from common acute lymphoblastic leukaemia HLA-DR antigens and contained high concentrations of terminal deoxynucleotidyl transferase. A course of the chemotherapy usually prescribed for common acute lymphoblastic leukaemia resulted in complete remission.
一名9岁儿童被发现其骨髓被恶性细胞大量侵袭。即使在对骨髓涂片进行电子显微镜研究和多次细胞化学染色后，经验丰富的病理学家也无法根据形态学依据确定这些细胞的性质。然而，对这些细胞的血清学分析表明，它们显示出一种常见急性淋巴细胞白血病细胞特有的抗原——HLA - DR抗原，并且含有高浓度的末端脱氧核苷酸转移酶。采用通常用于治疗常见急性淋巴细胞白血病的化疗方案后，患儿实现了完全缓解。
