Trapeznikov N N, Eremina L A, Imamaliev A S, Amiraslanov A T, Kondrat'ev V G
Vopr Onkol. 1981;27(8):12-8.
The results of treatment of 315 cases of osteogenic sarcoma are presented. Available methods of primary tumor therapy fail to prevent dissemination of neoplastic disease by blood circulation. However, following a prophylactic course of chemotherapy (adriamycin, vincristine, cyclophosphamide, sarcolysine), 3- and 5-year survival rates in 45 cases of limb amputation for osteosarcoma increased to 38.1% and 30.5%, respectively. No recurrences were observed in 39 patients with extensive segmental resection of bone who preoperatively received intra-arterial infusions and radiation therapy; the 3-year survival rates were a high as 43.9% and patients showed good performance. The method offers good advantages in the treatment of patients with osteogenic sarcoma.
本文报告了315例骨肉瘤的治疗结果。现有的原发性肿瘤治疗方法无法防止肿瘤疾病通过血液循环扩散。然而，在进行了一个疗程的预防性化疗（阿霉素、长春新碱、环磷酰胺、溶肉瘤素）后，45例因骨肉瘤行肢体截肢术患者的3年和5年生存率分别提高到了38.1%和30.5%。39例术前接受动脉内灌注和放射治疗并进行广泛节段性骨切除的患者未观察到复发；3年生存率高达43.9%，患者表现良好。该方法在骨肉瘤患者的治疗中具有良好的优势。
