Bosu W T, Doig P A, Barker C A
Can Vet J. 1981 Mar;22(3):59-61.
Fifteen Holstein cows were treated with two doses of 25 mg of a prostaglandin F(2)alpha (PGF(2)alpha as dinoprost tromethamine) administered intramuscularly 11 days apart. The cows were then divided into three groups and inseminated either at 72, 80 or 72 and 96 hours after the second dose of PGF(2)alpha. Thirteen cows ovulated after the second prostaglandin treatment. Eight cows were diagnosed pregnant by rectal palpation 42 days after insemination but only five calved. PGF(2)alpha induced luteolysis in cows with active corpora lutea as evidenced by the dramatic decreases in the plasma progesterone concentrations after treatment. In contrast, following PGF(2)alpha administration to cows in follicular or late luteal phase the concentrations of plasma progesterone either increased gradually or remained low for several days before increasing to maximal levels. The ovulatory rate after the two doses of PGF(2)alpha11 days apart was high. However, the pregnancy rate after this treatment was influenced by other factors including abnormal ovarian function.
对15头荷斯坦奶牛分两次肌肉注射25毫克前列腺素F(2)α（前列腺素F(2)α为氯前列醇钠），两次注射间隔11天。然后将奶牛分为三组，在第二次注射前列腺素F(2)α后的72小时、80小时或72小时和96小时进行授精。在第二次前列腺素处理后，13头奶牛排卵。授精42天后，通过直肠触诊诊断出8头奶牛怀孕，但只有5头产犊。前列腺素F(2)α可诱导有活性黄体的奶牛发生黄体溶解，治疗后血浆孕酮浓度显著下降即证明了这一点。相比之下，对处于卵泡期或黄体后期的奶牛注射前列腺素F(2)α后，血浆孕酮浓度要么逐渐升高，要么在升高到最高水平之前的几天内一直保持较低水平。间隔11天两次注射前列腺素F(2)α后的排卵率很高。然而，这种处理后的妊娠率受包括卵巢功能异常在内的其他因素影响。
