Bosu W T, Turner L
Can Vet J. 1983 Aug;24(8):253-7.
Daily changes in the plasma progesterone concentrations were determined in eight mares treated with intramuscular injections of 250 mug cloprostenol, a prostaglandin analogue, followed five days later by 2500 I.U. human chorionic gonadotropin. A second cloprostenol injection was given 14 days after the first; the mares were then inseminated on the third and fifth day of the subsequent estrus and a second injection of human chorionic gonadotropin was administered on the fifth day. The onset of estrus following the second cloprostenol treatment was synchronized beginning three to four days after treatment in all eight mares. All eight ovulated, five mares conceived and only four foaled. Evaluation of the progesterone profiles provided reliable indicators of luteolysis, ovulation and luteal function. Decreasing plasma progesterone concentrations were associated with cloprostenol induced luteolysis or preceded spontaneous onset of estrus. The plasma progesterone concentrations increased consistently after ovulation, and in the pregnant mares, the progesterone concentrations remained high during the first month after insemination.
对8匹母马进行了血浆孕酮浓度的每日变化测定。这些母马先肌肉注射250微克氯前列醇（一种前列腺素类似物），5天后再注射2500国际单位人绒毛膜促性腺激素。在首次注射氯前列醇14天后进行第二次注射；随后在接下来发情期的第3天和第5天对母马进行授精，并在第5天进行第二次人绒毛膜促性腺激素注射。在所有8匹母马中，第二次氯前列醇治疗后发情的开始在治疗后3至4天开始同步。所有8匹马都排卵，5匹母马受孕，只有4匹产驹。对孕酮曲线的评估提供了黄体溶解、排卵和黄体功能的可靠指标。血浆孕酮浓度下降与氯前列醇诱导的黄体溶解有关，或在发情自然开始之前出现。排卵后血浆孕酮浓度持续升高，在怀孕母马中，授精后第一个月孕酮浓度保持在高位。
