Gavaghan T E, McNaught P J, Ralston M, Hayes J M
Aust N Z J Med. 1981 Jun;11(3):261-5.
Goodpasture's syndrome is a recognised but rare complication of penicillamine therapy. Return of useful renal function has no been recorded with this complication. A patient is presented in whom aggressive management with plasmapheresis, haemodialysis and immunosuppression in the acute stage resulted in rapid control of pulmonary haemorrhage and return of useful renal function without the need for long-term haemodialysis. Immunofluorescence and electron microscopic studies of renal tissue together with the demonstration of circulating immune complexes, established the immune complex pathogenesis of this patient's disease. Microhaematuria is emphasised as an important warning sign of this complication.
Goodpasture综合征是青霉胺治疗中一种已被认识但罕见的并发症。这种并发症尚无有用肾功能恢复的记录。本文报告了一名患者，在急性期采用血浆置换、血液透析和免疫抑制的积极治疗，迅速控制了肺出血，且无需长期血液透析，有用肾功能得以恢复。对肾组织进行免疫荧光和电子显微镜研究，并证实循环免疫复合物的存在，确定了该患者疾病的免疫复合物发病机制。镜下血尿被强调为该并发症的一个重要警示信号。
